Development of an electronic Poor Outcome Screening (ePOS) Score to identify critically ill patients with potential palliative care needs - Luethi, N.; Wermelinger, S. D.; Haynes, A. G.; Roumet, M.; Maessen, M.; Affolter, B.; Muller, M.; Schefold, J. C.; Eychmueller, S.; Cioccari, L. (J Crit Care, 2022)
PURPOSE: To develop and validate an electronic poor outcome screening (ePOS) score to identify critically ill patients with potentially unmet palliative care (PC) needs at 48 hours after ICU admission. MATERIALS AND METHODS: Retrospective single-centre cohort study of 1'772 critically ill adult patients admitted to a tertiary academic ICU in Switzerland between 2017 and 2018. We used data available from electronic health records (EHR) in the first 48 hours and least absolute shrinkage and selection operator (LASSO) logistic regression to develop a prediction model and generate a score to predict the risk of all cause 6-month mortality. RESULTS: Within 6 months of the ICU admission, 598 patients (33.7%) had died. At a cut-off of 20 points, the ePOS score (range 0-46 points) had a sensitivity of 0.81 (95% CI 0.78 to 0.84) and a specificity of 0.51 (0.48 to 0.54) for predicting 6-month mortality and showed good discriminatory performance (AUROC 0.72, 0.67 to 0.77). CONCLUSIONS: The ePOS score can easily be implemented in EHR and can be used for automated screening and stratification of ICU patients, pinpointing those in whom a comprehensive PC assessment should be performed. However, it should not replace clinical judgement.
Keywords: journalArticle; *Critical Illness; *Intensive Care Units; Abbott-Nutrition-International, Braun-Medical-AG, CSEM-AG, Edwards-Lifesciences-; Adult; Bard-Medica-S.A., Abbott-AG, Anandic-Medical-Systems, Pan-Gas- AG-Healthcare,; Bracco, Hamilton-Medical-AG, Fresenius-Kabi, Getinge-Group-Maquet-AG, Drager-AG,; Cohort Studies; Covidien, and Nycomed. The money was paid into departmental funds. No personal; Electronics; Eli-Lilly-and-Company, Baxter, Astellas, Astra-Zeneca, CSL-Behring, Novartis,; Hospital Mortality; Humans; Intensive care; Omnicare-Clinical-Research-AG, Nestle, Pierre-Fabre-Pharma-AG, Pfizer,; Palliative Care; Retrospective Studies; Services-GmbH, Kenta-Biotech-Ltd, Maquet-Critical-Care-AB,; Teleflex-Medical-GmbH, Glaxo-Smith-Kline, Merck-Sharp-and-Dohme-AG,; end-of-life care; financial gain applied; grants outside of the submitted work from Orion-Pharma,; interests. SW, JCS and LC report (full departmental disclosure) departmental; mortality; outcome; prediction scores