Adjunctive hyperbaric oxygen combined with surgery and antifungal therapy for the management of soft tissue mucormycosis: a case report and review of the literature - Kapustin, P.; Munting, A.; Desgraz, B.; Menager, E.; Bruhlmann, J.; Corbaz, J.; Pham, T. T.; Meylan, S.; Wagner, D.; Harder, Y.; Lamoth, F. (2026)
Soft tissue mucormycosis is a rare fungal infection that can develop on contaminated wounds. We report a case of Mucor circinelloides ankle infection in an immunocompetent man following a high-energy motorcycle accident, which has successfully been treated by surgery (multiple debridements, arthrodesis, soft tissue defect reconstruction with flap and skin graft), systemic antifungal therapy (initial liposomal amphotericin B followed by isavuconazole) and hyperbaric oxygen. This case highlights the therapeutic challenges and need for a multidisciplinary approach of such infection.
Keywords: journalArticle; *Antifungal Agents/therapeutic use; *Hyperbaric Oxygenation/methods; *Mucormycosis/therapy/microbiology/drug therapy/surgery/diagnosis; *Soft Tissue Infections/therapy/microbiology/surgery/drug therapy; Accidents, Traffic; Adult; Amphotericin B/therapeutic use; Arthritis; Combined Modality Therapy; Cutaneous mucormycosis; Debridement; Hospital). All other authors: no competing interest to disclose; Humans; Isavuconazole; Male; Mucor/isolation & purification; Mucorales; Nitriles/therapeutic use; Osteomyelitis; Pfizer, Mundipharma and Becton-Dickinson, outside of the present work. All; Pyridines/therapeutic use; Surgical Flaps; Triazoles/therapeutic use; and Novartis, and honoraria for conferences or advisory boards from Gilead, MSD,; contracts were made with and fees paid to his institution (Lausanne University